Akero is on track to report 36-week treatment data from the phase IIb SYMMETRY main study, evaluating EFX in adult patients with cirrhotic NASH in fourth-quarter 2023. Based on this data, Madrigal initiated a rolling new drug application (NDA) submission last month seeking accelerated approval for resmetirom to treat NASH with liver fibrosis.Īkero Therapeutics is evaluating its lead candidate efruxifermin (EFX) for treating NASH. The study achieved its primary endpoints and potentially clinically meaningful effects compared with placebo. Last December, Madrigal reported positive top-line data from the pivotal phase III MAESTRO-NASH study evaluating its resmetirom for treating NASH and liver fibrosis. Madrigal Pharmaceuticals is developing its lead candidate resmetirom for treating NASH and liver fibrosis. While the NASH market holds potential with no approved therapies yet, it is challenging as several companies like Madrigal Pharmaceuticals MDGL and Akero Therapeutics AKRO are trying to develop a successful treatment for the same. NASH is a progressive form of non-alcoholic fatty liver disease, characterized by excessive fat buildup in the liver, accompanied by inflammation and fibrosis, which may progress to cirrhosis, liver failure, cancer and death. Management plans to report 52-week treatment data from this study in first-half 2024. In fact, 85% of patients who received VK2809, experienced at least a 30% relative reduction in liver fat content. The VOYAGE study achieved its primary endpoint of statistically significant reduction in liver fat content in NASH patients following 12 weeks of treatment with VK2809. In May, Viking Therapeutics reported positive data from an ongoing phase IIb study (VOYAGE) evaluating VK2809 in patients with biopsy-confirmed non-alcoholic steatohepatitis (“NASH”). Shares of Viking Therapeutics suffered a negative impact following Lilly’s announcements. LLY also completed the regulatory submission seeking label expansion for its dual GIP/GLP-1-RA drug tirzepatide to treat obesity or overweight in adults, with a final decision expected before this year’s end. Last month, Lilly reported new data from multiple mid-stage studies, evaluating different obesity drug that achieved a mean weight reduction of up to 24%. Eli Lilly is running multiple comprehensive clinical development programs evaluating different drugs for treating obesity in patients, with or without diabetes, which can be administered orally or by injections. The initiation is likely in response to the ongoing obesity drug wave wherein several large-cap pharma companies like Eli Lilly LLY, Novartis and Pfizer are evaluating oral formulations for treating obesity.Įarlier this year, several pharma companies reported positive data from multiple studies evaluating their obesity drugs. Based on these results, Viking intends to start a phase II study evaluating VK2735 to treat patients with obesity by mid-2023.īased on the results, Viking Therapeutics initiated an early-stage extension study to evaluate the oral formulation of VK2735 with highly-differentiated dosing options in healthy adults. Management also believes that the tolerability data from this study suggest that higher doses of VK2735 may be achieved with longer titration windows. Data from the study demonstrated up to 6% placebo-adjusted mean weight reduction (7.8% from baseline), following 28 days of treatment with VK2735. In March, Viking Therapeutics reported encouraging data from the recently completed early-stage clinical study evaluating its dual GIP/GLP-1-RA drug VK2735 administered subcutaneously across various metabolic disorders. The upside can be attributed to the successful development of its pipeline candidates targeting various metabolic and endocrine disorders.
0 Comments
You can download and print the the March 2016 calendar page by clicking here. And shamrocks …Īnd can I just say how wonderful it’s been to get your emails asking if I plan to continue the free printable calendar pages throughout 2016? It truly heartens my heart that you love these pages as much as I love creating them! 4.9 stars - based on 11 reviews / share your feedback. Get your free trial Send me download link Buy now Supported languages. And we won’t be seeing any sign of Spring until April or May. kalnirnay Kalnirnay English Office Small Calmanac 2016 2016 Wall Calendar at best prices with FREE shipping & cash on delivery. Compatible with SharePoint 2019, 2016, 2013, and 2010. Knocking Easter out of the running.Īnd then there’s Chicago. There’s the first day of Spring.īut I thought it best to be non-denominational. Included in the community helpers calendar cards set: Small Calendar Cards Large Calendar Cards Calendar notebook pages for PreK and Lower Elementary. Mason Jar Calendar: Free Printable Calendar Page for March 2016.Īnother month, another free calendar page printable. It doesn’t help that these celebrities get lesser punishments than “regular” people. It is almost as though we are condoning this sort of behaviour and lifestyle as being acceptable. With role models like Britney Spears, who only a few years ago had an emotional breakdown, and Lindsay Lohan, who has been in and out of jail and rehab, what can we expect of the youth?Īnd the worst part is that these people are still famous and constantly talked about. Is this the sort of example we want to give to the youth of today? That by acting out and behaving badly we can get more attention and become famous? No wonder young people can be so out of control these days. Smoking, endorsing drugs and alcohol and being susceptible to drunken rages have given him even more attention and made him even more famous than he was 12 months ago. He has been the highest paid TV actor for years now, earning $2 million per episode of Two and a Half Men, and he has gone completely off the rails. The problem we face with having celebrities as role models is that if they start endorsing issues which are not positive, it can very easily lead us astray. This idolisation of celebrities can be positive because it gives young people someone to look up to. Celebrities like Paris Hilton and the Kardashian sisters are but a few examples. In more recent times, movie stars and musicians have become the idols in our lives. In many countries the kings and queens or people of power gained respect and their subjects longed to be just like them. In Greek mythology Hercules was the celebrity of the day. Feel free to carry on the discussion by replying to each other’s posts (including mine).Young people deserve positive role models, yet too many modern-day celebrities offer bad examples, writes 18-year-old Amanda McClintock from Queensland, Australia.įor as long as there have been humans on this Earth there have been the people who we look up to as our heroes and celebrities. No one was interested in Tiger Woods’ personal life until this recent development, right? At the same time, however, a lot of the good things about these celebrities don’t get the spotlight. It really all depends on who you’re talking about. How interesting is a story about a celebrity doing charity work when there is so much other “dirt” going on? What does this tell you about what we learn about celebrities and news media? Let’s face it, shows like ET and TMZ, and magazines like People, In Touch and the National Enquirer tend to portray only the negative aspects of celebrity life and that shapes our perception of them. It would seem that the majority of you feel that celebrities are not good role models, mainly because of what you see in the public eye. I could comment on each one individually but I think I might be sending the same message in each. Wow! There are a lot of interesting comments in this post. But in the end its your life you choose who your like and who your not no one controls you. Know see the article only tells you about the bad side of being famous, but really you just have to pick and choose your star s because everyones different. Such as”Taylor swift, Justin bieber and selena gomaz.” They act like there not famous, So down to earth. Then there are the people that are just the kindest people and you feel as if you’ve know them your entire life(insted of not all).Whom you really look up too, they donate there time to people less then them. But still when it dose come they think can get out of it with money or fame, they act as if there above the lawbecause the famous. Then there are the people who make bad decisions all the time and know it.Who don’t really care about it ethier intill the pentalty comes. Now some people who happen to be celebritys that are bad influences are just the same as reagular people.We can all say we’ve had a few slip ups and thats all thats some of the things are that famous people get expolted for.Everyone gose thourgh fases and how come its so wierd when they do it but everyone dose it? such as ” miley cyrus, joe jonas and hillary Duff.’ I think that it all depends on the celebrity that your looking at when you say “is she/he a good role model?”, because everyone is different and when you label someone as a celebrity it dose not make them a bad person. 28, 2011 Alex Wong / Getty Images In 2003, when France opposed going to war in Iraq, the U.S. We look forward to serving you once again. French Fries to 'Freedom' Fries By Alexandra Silver Monday, Mar. Get away to some place more exotic - Chart House in Longboat Key is the perfect Sarasota restaurant.Īs we reopen our dining rooms, we will continue to practice and take part in preventative measures to ensure the safety of you and your family. This tropical retreat is just west of Sarasota on Gulf of Mexico Drive, and within driving distance of beautiful outdoor destinations such as South Lido County Park and Bay Island Park and near boat rentals, bike tracks and more. Located on gorgeous Longboat Key, Chart House is practically a vacation spot in and of itself. Sip on cocktails and enjoy Happy Hour specials from our comfortable bar seating or dine on a romantic meal of delicious seafood specialties with a local twist. Whether you're in the dining room or on the terrace overlooking the gorgeous Gulf waters of Sarasota Bay, Chart House seafood restaurant has just the right view to soothe your soul. Enjoy steak, chicken, ribs, fresh seafood & our famous Bloomin Onion. and psychological impact of the Woman, Life, Freedom movement through the. There's no better way to get away from the daily grind than to find a nice, relaxing spot at Chart House – one of the best Longboat Key waterfront restaurants. The home of juicy steaks, spirited drinks and Aussie hospitality. 100 Black Men of Long Beach & Black Young Men Meet Up - formal life skills. The statement further read: "This action today is a small but symbolic effort to show the strong displeasure many on Capitol Hill have with our so-called ally, France."ĭoesn't sound like they knew it was a joke.Longboat Key A Waterfront Destination near Sarasota According to a statement released by Ney, the renaming was intended to express displeasure with France's "continued refusal to stand with their U.S. By creating an account you are able to follow friends and experts you trust and see the places they’ve recommended. ' (2 Tips) See what your friends are saying about Five Guys. French fries are downright addictive and the perfect food for almost any occasion: a side at a cookout, a midday snack or a late-night wine session. With the restaurant in his district, Jones chose to follow its example by circulating a letter to his colleagues advocating their renaming because, he said, "the French were 'sitting on the sidelines.'" As Ney was Chairman of the United States House Committee on House Administration, the action did not require a congressional vote, as the committee has authority over the House cafeterias. The franchise restaurant that serves up gourmet fries on Artesia Boulevard in North Long Beach is a family affair, owned and operated by Deonta Douglas, 31, his mom Yolanda Cooper, his surrogate brothers Joron, 25, and Devin Green, 31, and Carlton Capiti, 30, and their mother Nichole Reaves. 74 ratings ' Overload on fries )' (2 Tips) ' Cajun fries are what you need.' (2 Tips) 'Bacon cheeseburger is all you need' (3 Tips) ' Bacon Burger. Jones directed all three House cafeterias to change all references to French fries and French toast on menus, and replace them with Freedom fries and Freedom toast, respectively. So even though they officially renamed it, we should have all realized it was a joke, even though they were publicly criticizing France, and they don't normally joke. There are three broad dynamics amongst stakeholders that will determine Germany’s China policy. But which strategic direction will it follow? This year, the new traffic light coalition will draft Germany’s first-ever China strategy. Now, German China policy is at an inflection point. So too did Angela Merkel herself, to some degree, when she acknowledged that Germany may have been " too naive in our approach to some cooperation partnerships". Former advisors and ministers in Merkel’s cabinet have grasped this as an opportunity to distance themselves from past policies. The inauguration of the new German government has offered a necessary break. Doing so would have openly admitted failure of a long-standing policy. Despite this shift, Berlin was incapable of departing from its political course. Beijing has become both more authoritarian domestically and antagonistic internationally. This change has, however, been for the worse, not the better. Over the course of Angela Merkel’s 16-year tenure, China has changed. Driven by the Merkel Chancellery, under the guiding principle of Wandel durch Handel (change through trade), Germany pursued a transparent policy of engagement in the hopes of influencing China to become more liberal and democratic.īut this constellation has ended, or rather, it has failed. In the past, it was underpinned by a clear selection of people, principles, and policies. Germany’s China policy is at sea, drifting without an anchor. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |